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Point Mutation in CREB1 Associated with Increased Fear of the Negative Health Consequences of CREB1 Associated SNPs

Fear of SNPs Associated with SNP

By Everyday JunglistPublished 3 years ago 4 min read
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A cartoon representation of a molecule which could contain a point mutation (single nucleotide polymorphism/SNP). Image courtesy of Pixabay. The bay Pixies pick when they need to pick a bay to stay today or anyday.

In an ironic finding of unknown significance researchers today published a paper which established for the first time that a single nucleotide polymorphism (SNP) in the gene CREB1 is associated with increased fear of the negative health consequences of single nucleotide polymorphisms in both the CREB1 locus and CREB1 gene. The linkage was found through a statistical analysis of data from the Heritage family study combined with surveys and genetic screening of 500 healthy persons who did not have an abnormal and irrational fears of the negative health consequences of CREB1 associated SNPs and 250 healthy persons who did hold such unusual, irrational, and abnormal fears. The population of CREB1 SNP fearers were not abnormally afraid of SNPs in any other health risk associated gene or locus but only of those associated with CREB1 point mutations. Until today it was not known why such specific fears were so prevalent. By regression analysis the single point mutation in the CREB1 gene accounted for 20% of the variance in fear to SNPs in the CREB1 gene associated with health risks, but only 2.3% of the variance to other SNPs in the CREB1 locus. No linkage was seen to SNPs in any other genes or loci previously associated with health risks. Researcher Dr. Stephen Tribalt said the following at a news conference announcing the result “We were intrigued by the question of the unusually high level of fear of SNPs in the CREB1 gene and gene locus and set out to find the reason why. We had hypothesized that a SNP might be responsible since, as we are learning more each day, SNPs are responsible for virtually all human physical and mental ailments. That said when we discovered that the SNP we were searching for resided in the CREB1 gene itself we were very surprised, and confused, very, very confused. Although it is a surprising and ironic finding the data supporting our conclusion is rock solid. We only needed 15 test adjustments before a statistically significant association was found in the data set. That’s great, right?, right?” At that point Dr Tribalt looked down sadly, sighed, then turned and slowly left the podium.

This Is An Easy One - A Simple Answer To A Complicated Question

Is this the answer to a medical mystery? Read on to find out. Courtesy of pixabay.

I happened to stumble across this article the other day (linked below) in the Medium features section and immediately recognized I had the answer to the question posed in the title. If you read it (I did not) you will be bombarded with all manner of medical mumbo-jumbo and scientific hypotheses which give smartly reasoned yet overly complex explanations for this mystery.

Why Is Everyone Getting Shingles?

It turns out the answer is pretty obvious, without shingles a roof will not keep you dry. Basically until you cover your roof with shingles it is just plywood over some insulation and beams. The first time it rains the plywood will soak through, and once it is fully saturated will eventually begin to drip into your home. After a time mold will start to grow and then the wood will rot. You need to get shingles well before this point as you do not want this to happen to you. I know what it is like to live in a home without shingles and it sucks. I say go out there and get as many shingles as you can afford. I would even suggest stockpiling shingles in case of an emergency. That way if you ever need to move into a home you can quickly rain proof it with a little elbow grease, and a lot of help from our good friend, shingles. Rather than asking sarcastically why so many people are getting shingles maybe we should be asking why more people aren’t getting shingles? In my view not nearly enough people recognize the importance of shingles. Our time would be better served reading and writing articles which highlight the many positives of shingles, instead of bashing them for reasons I can’t understand. In fact I would go so far as to call this article anti-shingle which is downright disturbing in this day and age. What next, why are gutters on the rise in children? Why are all our pets getting windows? When will it end? Where will it stop? It is just plain sick and I for one won’t stand for it. Who’s with me? I need to go throw up.

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About the Creator

Everyday Junglist

Practicing mage of the natural sciences (Ph.D. micro/mol bio), Thought middle manager, Everyday Junglist, Boulderer, Cat lover, No tie shoelace user, Humorist, Argan oil aficionado. Occasional LinkedIn & Facebook user

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