Having inherited the title of CEO of a genetic research company from her late father, Bridget Pellegrini (Erika Hoveland) does not take her job lightly and is stringent in following her father's example of never compromising her principles. So after learning that her company's latest business venture incurs moral and legal ramifications, she's quick to veto any further developments on the project. But with that project serving as a means of allowing people to achieve immortality, more than a few employees are left furious by Bridget's decision.
Autumn Bailey (Kayla Wallace) is disheartened to find herself starting over at a new school, having had to move with her mother Cynthia (Kehli O'Byrne) as part of her new job. But soon after arriving at her new school, Autumn finds herself making fast friends with social outcast Kara (Maddie Phillips), as well as attracting the attention of cheerleader Jenny (Samantha Schimmer). While reluctant to try out for the team, Autumn is convinced by Kara to go out for cheerleading as an undercover journalist for the school paper, hoping to expose the culture of cruelty within the cheer team.
Cassie Talbot (Alexandra Beaton) is a small-town girl who's just been accepted into a prestigious university, Tate Reilly, along with her best friend, Alyssa (Bukola Walfall). Soon after arriving on campus, Cassie meets Alyssa's former friend Gabby Sanders (Joelle Farrow), a member of Tate Reilly's cheerleading squad who convinces Cassie to try out for the team. While Cassie's audition wows the team, and earns a spot on the squad, she soon after learns from her mother, Karen (Cynthia Preston), that her absentee father has dropped off the grid, leaving them scrambling to find a way to pay for Cassie's tuition.
Things are already rough enough for 17-year-old Jane Morgan (Hannah Vandenbygaart), as she finds herself caught in the middle of her parents' rocky separation. One night, while being driven home by her father Paul (Scott Gibson), the two are involved in an accident, which leaves Jane with an injured leg. Already on edge due to her parents' separation, Jane is further upset to learn that her father moved out of the house while she was in the hospital—and her mother Sam (Jessalyn Gilsig) has a younger boyfriend in physical trainer Brian (Jon Cor).
After narrowly surviving a car crash, Leah (Chelsea Hobbs) finds herself not only on the verge of being charged with drunk driving and auto theft, but with no memory of the crimes she supposedly committed or what led up to the accident. With Officer Barrett (Klea Scott) intent on keeping her in prison until her identity can be uncovered, Leah appears to only have two people in her corner: pro-bono lawyer Rick (Mark Famiglietti) and Dean (William McNamara), who introduces himself to Leah as her husband.
When Jennifer Davis (Gabrielle Stone) arrives in the small town of Chestnut Hill, she initially appears to be an average girl. Soon after her arrival, she meets bar owner Greg Wells (Dan McGlaughlin), and earns herself a job as his bar's new cook—much to the annoyance of Greg's girlfriend, Sarah (Samantha Fairfield Walsh).