Probiotic supplementation may be beneficial for adults with severe depressive disorder, according to recent research.

According to a recent study that was published on June 14 in JAMA Psychiatry, people who are using antidepressants to treat major depressive disorder may benefit from adding a probiotic blend with 14 different bacterial strains to their diet. The study showed the potential of probiotic supplementation to support improvements in multiple depression and anxiety scores over an eight-week period. It was conducted by the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London in collaboration with ADM Protexin, a division of ADM.

One of the first studies in a Western population to demonstrate both probiotics' good tolerability and their beneficial benefits on the mental health of individuals with depression who are currently taking antidepressants is the pilot research. The findings, in the opinion of the study's researchers, offer a solid foundation for additional research into the advantages of this probiotic dietary supplement for promoting mood and mental health in a bigger trial. There is mounting evidence that the gut microbiota, a diverse and ever-evolving colony of microorganisms, is involved in mood regulation. The study was intended as an initial investigation into the possibility that using probiotics—supplements containing beneficial bacteria—could function as a new channel for enhancing gut health.

In this pilot study, a proprietary 14 strain blend probiotic supplement that is widely available was given to 49 persons with major depressive illness who had received only a partial response to prescription antidepressants or an equivalent placebo (24 getting the probiotic). Both groups showed improvement in their symptoms over the course of eight weeks, however the probiotic group experienced bigger benefits starting in week four. By comparing claimed improvements to the gold standard rating scales for depression and anxiety, significant improvements were seen.

"Non- or partial response to antidepressants is a huge problem, and this study is an important first step in examining the therapeutic potential of probiotics as a treatment for depression," said Professor James Stone, the study's senior investigator who started the work at King's IoPPN and is now at BSource: Medical Xpress: June 14, 2023

Probiotics were a well-tolerated and acceptable supplement in patients using antidepressants, according to our research. This opens the door for investigations investigating whether probiotics have these positive effects on sadness and anxiety in wider patient populations.

The gut-brain axis is a genuinely exciting and quickly developing area of microbiome research, according to the study's first author, Dr. Viktoriya Nikolova of King's IoPPN. Our understanding of the function of probiotics in mood and mental health has advanced significantly as a result of the outcomes of this pilot study.

According to the World Health Organization, an estimated 5% of adults experience depression, with a sizable portion of those individuals not fully responding to conventional treatment choices, according to Dr. Richard Day, vice president of medical affairs at ADM. This trial is one of the few clinical trials to examine the advantages of adding probiotics to the diet in addition to antidepressant medications that are already prescribed. We now know more about the relationship between the gut microbiome and mental health thanks to these fascinating studies.

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Source: Medical Xpress: June 14, 2023