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BEST WEIGHT LOSS MEDICATIONS.

Are Weight Loss Medications Effective? Insights from a Dietitian Prescription weight loss medications, including GLP-1 agonists, orlistat, and setmelanotide, can be effective for some individuals. However, long-term success still relies on lifestyle changes.

By william jane Published about a month ago 8 min read

Are Weight Loss Medications Effective? Insights from a Dietitian

Prescription weight loss medications, including GLP-1 agonists, orlistat, and setmelanotide, can be effective for some individuals. However, long-term success still relies on lifestyle changes.

For those struggling to lose weight despite dietary adjustments and increased physical activity, prescription weight loss medication might be an option. These medications typically work through mechanisms such as:

  • Reducing appetite, making you feel fuller, so you consume fewer calories
  • Reducing the absorption of nutrients like fat, resulting in fewer calories absorbed
  • Increasing metabolism, helping you burn more calories

When combined with other lifestyle changes and taken under medical supervision, these drugs can effectively aid in weight loss.

FDA-Approved Weight Loss Medications

The FDA has approved several medications for weight loss in people with overweight and obesity. These medications require a prescription and medical supervision:

  • GLP-1 agonists: liraglutide (Saxenda), semaglutide (Wegovy), tirzepatide (Zepbound)
  • Orlistat: (Xenical)
  • Phentermine/topiramate: (Qsymia)
  • Naltrexone/bupropion: (Contrave)
  • Setmelanotide: (Imcivree)
  • Appetite suppressants: phentermine (Adipex-P, Lomaira)
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These medications should be combined with a balanced diet for sustainable results, as they are not likely to be a long-term solution on their own and may lead to weight regain after discontinuation. They also come with potential side effects, some of which can be serious.

Effectiveness of Prescription Weight Loss Drugs

Prescription weight loss medications can support weight management effectively. They usually work by reducing food intake, decreasing fat absorption, or boosting metabolism, leading to significant weight loss over time. Typically, these medications can result in a 5–10% reduction in body weight, though this varies depending on the medication and individual factors.

These medications should be used alongside dietary and lifestyle changes, such as regular physical activity, to enhance their effectiveness and help prevent weight regain after stopping the medication.

Pros and Cons of Weight Loss Medications

LAVASLIM WEIGHT LOSS

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Fucoxanthin: Targeting internal temperature, fucoxanthin also supports healthy cholesterol levels and liver function.

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Moringa: Another internal temperature regulator, moringa offers anti-aging effects and improves digestive health.

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Ginger Root: With its focus on internal temperature regulation, ginger root also aids in blood sugar management and reduces blood pressure.

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    GLP-1 Agonists

  • Examples: liraglutide (Saxenda), semaglutide (Wegovy), tirzepatide (Zepbound)
  • How they work: Slow stomach emptying, increase feelings of fullness, reduce glucagon secretion.
  • Effectiveness: Studies show significant weight loss, e.g., semaglutide resulted in nearly 15% weight reduction over 68 weeks.
  • Side Effects: Nausea, vomiting, diarrhea, dizziness, headaches, increased heart rate, infections, indigestion. Severe side effects can include kidney problems, thyroid tumors, gallbladder disease, low blood sugar, suicidal ideation.
  • Contraindications: Not recommended for individuals with certain endocrine disorders, thyroid cancer history, pancreatitis, severe gastrointestinal conditions, or those who are pregnant.

Orlistat (Xenical)

How it works: Blocks fat-breaking enzymes, reducing calorie absorption.

Effectiveness: Studies report an average weight loss of 10.3 pounds over six months.

Side Effects: Digestive issues like oily stools, gas, frequent bowel movements, potential nutrient deficiencies.

Contraindications: Chronic malabsorption, cholestasis, pregnancy, renal impairment.

Phentermine/topiramate (Qsymia)

How it works: Combines a stimulant and an anticonvulsant to reduce appetite and increase satiety.

Effectiveness: Studies show an average weight loss of 17 pounds over a year.

Side Effects: Dry mouth, constipation, pins and needles sensation, increased body temperature, psychiatric disturbances.

Contraindications: Glaucoma, hyperthyroidism, pregnancy, recent use of monoamine oxidase inhibitors.

Naltrexone/bupropion (Contrave)

How it works: Reduces food intake and boosts metabolism by acting on the brain.

Effectiveness: Significant weight loss, averaging 11–22 pounds in various studies.

Side Effects: Nausea, constipation, headache, dizziness, dry mouth, increased heart rate, blood pressure.

Contraindications: History of seizures, end-stage renal disease, pregnancy, use of certain medications.

Setmelanotide (Imcivree)

How it works: Activates melanocortin receptors to reduce hunger and increase metabolism.

Effectiveness: Around 62% of users achieve at least 10% weight loss after a year.

Side Effects: Injection site reactions, hyperpigmentation, nausea, headache, stomach or back pain.

Contraindications: Renal impairment, pregnancy, breastfeeding.

Appetite Suppressants

Examples: phentermine (Adipex-P, Lomaira)

How they work: Alter neurotransmitter levels to reduce appetite.

Effectiveness: Significant short-term weight loss, averaging 8.3 pounds over 12 weeks.

Side Effects: Nausea, vomiting, diarrhea, stomach cramps, shortness of breath, chest pain.

Contraindications: Heart disease, hypertension, hyperthyroidism, glaucoma, diabetes, pregnancy.

Who Are Weight Loss Drugs For?

Weight loss medications are typically approved for adults with obesity or those who are overweight with weight-related conditions like type 2 diabetes, high blood pressure, or high cholesterol. Setmelanotide is specifically for genetic obesity disorders.

These medications are for individuals who haven't achieved weight loss through diet and lifestyle changes alone. However, they are not suitable for everyone, especially those who are pregnant, have certain health conditions, or are on specific medications.

When to Talk to a Doctor

If weight loss remains elusive despite various efforts, consulting a healthcare professional about weight loss medications might be worthwhile. These medications can have serious side effects and are not safe for everyone, so professional guidance is crucial. Some digital weight loss platforms also include GLP-1 medications in their treatment plans for eligible individuals.

The Bottom Line

Prescription weight loss medications can be effective for meaningful weight loss when combined with dietary and lifestyle changes. They are not a quick fix and can lead to weight regain after discontinuation. A healthcare professional can help determine the right medication and incorporate it into a healthy weight management plan.

For best results, these medications should be part of a comprehensive approach, including a balanced diet, regular physical activity, and healthy lifestyle habits.

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About the Creator

william jane

EXPERT FOR HEALTH & FITNESS

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  • shanmuga priya30 days ago

    Thank you for sharing your work.

william jane Written by william jane

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