the next generation supplements for joint pain relief

Decades of oxidative stress and regular wear and tear have a negative impact on the structure of aged joints. While enhancing the tissue-rebuilding properties of glucosamine and other standard joint-health supplements, new chemicals can quickly reduce joint discomfort.

Adults with debilitating arthritic pain have recently had to decide between costly, sometimes deadly painkillers and safer, slower-acting remedies that promote joint health. Although it has been repeatedly demonstrated that supplements like glucosamine and chondroitin sulphate can improve both arthritis symptoms and joint functionality, it may take weeks or even months before the benefits are felt, providing little relief in the interim for people with severe, incapacitating joint pain.

Thankfully, a number of novel substances have been discovered that act swiftly to reduce pain and encourage quick healing, bridging the time between the start of suffering and the start of relief. These newer substances not only provide pain relief more quickly, but also gradually help joint healing and tissue regeneration by functioning broadly and comprehensively over time, either by themselves or in combination with conventional joint-health supplements.

New Tools to Combat Joint Pain

Adults who are concerned about their health and want to keep their joints in good shape have long relied on nutritional supplements like glucosamine, chondroitin sulphate, and methyl-sulfonylmethane (MSM). Although these supplements are helpful in reducing pain and promoting long-term joint health, substantial doses are necessary to reap the benefits to the fullest extent, which has been a downside. Their slow start to action is another disadvantage. Simply put, it takes time for these conventional supplements to start working; studies indicate that it could take two weeks or even longer to fully enjoy their effects. 1-8 This delay in apparent improvement may, understandably, lead some patients to forego therapy too quickly. Although patience is a virtue, it is only normal to feel pain when it occurs.

The good news is that researchers have made significant strides towards creating joint-health supplements with a quicker onset of effect. These extraordinary substances are impressive new weapons in the arsenal of pain management since they naturally nourish joint fluids and tissues while reducing joint pain and enhancing joint functionality in just hours or days. They consist of:

Keratin, which promotes the growth of strong antioxidant protection and healthy new joint tissue.

Hyaluronic acid, a crucial component of connective tissue in joints, was previously only available with a prescription and then only for injection into the joints.

Without the negative gastrointestinal and cardiovascular side effects associated with COX (cyclooxygenase) inhibitors like ibuprofen and Celebrex®, Korean Angelica is a herbal extract that acts on the central nervous system to combat pain.

antioxidant defence and assistance with joint repair

Due to both normal wear and tear and the pervasiveness of oxidative stresses, human joints are particularly susceptible to the effects of aging10. In order to combat the many factors that gradually deteriorate joint health, scientists have recently created a unique keratin compound.

Keratin promotes the health of joints via

providing essential components for joint healing and energising powerful enzyme-based antioxidants with inherent natural antioxidant action.

The majority of the connective tissue in the body, such as skin, hair, and teeth, is made of keratin, a group of basic proteins with a remarkably high concentration of the amino acid cysteine. Sulfur molecules, an essential component of joint tissue, are abundant in cysteine. Sulfur molecules generate an incredibly powerful connection when they come together. Most of the structural stiffness of keratin is provided by these "cysteine bridges."

In weight-bearing joints, which need both flexibility and resilience to work as efficient shock absorbers, such rigidity is a very desirable quality.

Sulfur contributes significantly and in a variety of ways to healthy joint tissue. Biological polymers, or compounds formed of smaller, similar molecules connected together, make up a portion of the structure of joints. Sulfation, which normally takes place in healthy joints, is the integration of sulphur molecules into these polymers. These sulfur-to-sulfur linkages contribute significantly to the flexibility and crush resistance of proteoglycans, which are protein-sugar polymers. Impaired sulphur metabolism, in contrast, is a feature of diseased joints. 11-16 Joints become painful and stiff when they can no longer effectively integrate sulphur into their structure.

Essential Lubrication to Cushion Joints: Hyaluronic Acid

The presence of synovial fluid in the joint cavities is necessary for comfortable joint motion. The main naturally occurring polymer found in synovial fluid around joints is hyaluronic acid. Hyaluronic acid, which is produced by specialised cells lining the fluid-filled sac around joints, creates a viscous, cushioning environment for joint cartilage, protecting these hard-working tissues from damage caused by friction. But when osteoarthritis is present, hyaluronic acid in the synovial fluid decreases in concentration, loses flexibility, and becomes less viscous. In order to maintain healthy joint function, appropriate hyaluronic acid levels must be maintained.

The American College of Rheumatology published recommendations encouraging the use of hyaluronic acid preparations for injection directly into the synovial areas of joints affected by arthritis, acknowledging the significance of hyaluronic acid in guaranteeing joint comfort. 20 While hyaluronic acid was originally thought to solely cure the symptoms of arthritis, doctors have recently noticed that it may really address the underlying causes of the condition. Supplemental hyaluronic acid appears to promote the body's production of new hyaluronic acid, as well as enhancing joint lubrication and reducing pain and inflammation. 20-22

Researchers conducted a randomised, placebo-controlled, double-blind research with 20 patients who had knee osteoarthritis to investigate if these positive effects could be replicated in humans. For two months, either a placebo or an oral hyaluronic acid supplement named Hyal-JointTM containing 80 mg each patient was given. Although the results have not yet been published, they show that, compared to patients who got a placebo, supplemented patients saw a statistically significant improvement in a standardised pain score.