science

The Science Behind Relationships; Humans Media explores the basis of our attraction, contempt, why we do what we do and to whom we do it.

A Glimpse Beyond the Rainbow
For centuries, we've painted our world with the familiar strokes of red, orange, yellow, green, blue, indigo, and violet. These are the hues that dance in rainbows, adorn masterpieces, and define the spectrum of visible light we perceive. But what if the canvas of human perception holds the potential for a color we've never truly seen? Recent rumblings in the scientific community suggest this might not be a far-fetched notion. While not a completely new wavelength of light, researchers are exploring the fascinating possibility of a "chimeric" color, a unique sensory experience born from the way our brains process existing colors under specific conditions.
By Axel about a year ago in Humans
Rajkot’s Leading Non-Ferrous Metal Die Casting Machine Manufacturers
Rajkot is prominent for its engineering prowess and manufacturing capabilities. Rajkot is one of the leading manufacturers of non-ferrous metal die-casting machines in India. Rajkot has also become a center for trade due to the ample supply of advanced die-casting equipment for the automobile, aerospace, electrical, and consumer goods industries.
By Radheindustries seoabout a year ago in Humans
Shock and Anger After Gunmen Kill More Than 20 Tourists in Kashmir
The scenic valleys of Kashmir, frequently referred to as 'Paradise on Earth,' were marred by violence and sorrow when gunmen executed a vicious attack on tourists, resulting in the deaths of over 20 individuals in one of the most lethal assaults in recent history. This tragic event has reverberated throughout India and beyond, igniting outrage, condemnation, and heightened worries regarding safety in this troubled area.
By Tech Alaminabout a year ago in Humans
Bouclé Bed
The Bouclé Bed Combines Cozy Comfort and Classic Elegance Cozy, tactile, and aesthetically pleasing furnishings that instill a sense of warmth and personal sanctuary have been the focus of recent home decor trends. The bouclé bed is one piece of furniture that perfectly embodies this movement. The bouclé bed has become a popular choice for homeowners and interior designers alike due to its luxurious yet minimalist design and supple, textured fabric. A bouclé bed is a sophisticated yet comfortable addition that transforms your sleeping space into a chic retreat, whether you are renovating your bedroom or moving into a new home. Let's take a deeper look at what sets this bed apart and how it fits in with contemporary interior design trends. How Does a Bouclé Bed Work? The French word for "curled" or "looped" is the origin of the word "bouclé," which can be pronounced boo-clay. Wool is the most common fiber used to make bouclé fabric, but it can also be made with cotton, silk, or synthetic yarns. The defining feature of this fabric is its looped or nubby texture, which gives it a plush and cozy appearance.
By shanabout a year ago in Humans
10 Habits of People Who Always Seem to Have It Together
We all know that person. The one who somehow manages to stay on top of their work, make time for self-care, remember everyone’s birthday, and still show up looking like they got eight hours of sleep and drank enough water.
By Jeno Treshan about a year ago in Humans
The Illusion of Reality: How Your Brain Writes the World You Live In
The world you see is not real – you're not living in this very moment that you are experiencing and nothing is like it seems. It turns out your brain constructs your reality as you are experiencing it, it edits your memories as they happen, it lives in totally different time spheres and tells you a story about the world that feels real. What's going on and who is really in control of your life?
By Hillaryabout a year ago in Humans
Cosmic Bloom: The Awakening Within
Mis-splicing of ASD-risk genes in DM1 prefrontal cortex Executive functions are coordinated by the prefrontal cortex, which undergoes transcriptome-wide changes in individuals with ASD25,34. We looked at RNA sequencing (RNA-seq) data from Brodmann area 10 (BA10) of the human DM1 brain to see if the DMPK-CTGexp mutation causes ASD-risk gene RNA mis-splicing in the prefrontal cortex. To reduce age and sex biases, unaffected control samples were matched (Fig. 1a)35,36,37. We calculated the change in "percent spliced in" (PSI) for five AS event types for differential AS analysis (Fig. 1b). 1 percent (1,844) of the 184,000 AS events and 16,000 genes in DM1 met our mis-splicing criteria (PSI > 0.1, FDR 0.05) out of the total pool of 7 percent (1,261) of mis-spliced genes (Extended Data Fig. 1a). All mis-spliced events, including retained intron (RI) events, had a strong positive correlation between CTGexp repeat length and mean PSI values (Fig. 1c and Extended Data Fig. 1b). Consistent with previous research, we observed a negative correlation between the level of intron inclusion and the steady-state level of the host transcript (Extended Data Fig. 1c)38,39, despite the fact that not all RIs introduce a premature termination codon that causes nonsense-mediated decay. We retrieved 38 gene sets and available databases to assess the relevance of DM1 mis-splicing to ASD (Supplementary Table 1), and found that some mis-spliced RI events represented additional RNA species, such as an elevated circular intronic RNA level in DM1 (Extended Data Fig. 1d). After applying more stringent mis-splicing criteria (|PSI| > 0.2), we discovered a significant enrichment of mis-spliced events in 61% of the gene sets (Extended Data Fig. 1e), indicating a consistent trend (Pearson's r = 0.79, P 0.0001). Negative control gene sets (such as genes related to the immune system or metabolism) did not show any enrichment. Notably, the Simons Foundation Autism Research Initiative (SFARI) database and two large Autism Speaks MSSNG-based whole-genome sequencing studies, MSSNG-2017 (ref. 40) and MSSNG-2022 (ref. 40), both showed significant enrichment of ASD-risk genes. 41) (Fig. 1d and Fig. 1e of the Extended Data). SCN2A, ANK2, and SHANK2 were misspliced in DM1 out of 36 overlapping high-confidence ASD-risk genes in both the MSSNG-2017 and MSSNG-2022 studies (Fig. 1e, f, and Extended Data Fig. 1f). In addition, we discovered missplicing in the DMD gene, which is known to be the cause of Duchenne muscular dystrophy and ASD42,43. In addition, we found a strong positive correlation between misspliced events in ASD-risk genes and CTGexp length (Fig. 1g and Extended Data Fig. 1g). These findings, taken as a whole, suggested that the DMPK-CTGexp in the DM1 prefrontal cortex alters the splicing of genes associated with ASD risk.
By Mahafuj Alamabout a year ago in Humans
MBNL Sequestration Links Myotonic Dystrophy to Autism via RNA Mis-Splicing
Abstract Autism spectrum disorder has been linked to enrichment of gene-specific tandem repeat expansions across the genome. The CTG tandem repeat expansion in the DMPK gene's 3′ untranslated region, which is known to cause myotonic muscular dystrophy type 1, is one such mutation. Myotonic dystrophy and autism have a clear clinical connection, but the molecular basis for this connection is unknown. During brain development, the RNA splicing patterns of autism-risk genes, particularly a class of autism-relevant microexons, are altered when mutant DMPK RNAs with expanded CUG repeats sequester MBNL splicing factors. We show that both DMPK-CTG expansion and Mbnl null mouse models replicate autism-relevant mis-splicing profiles, as well as altered responses to novelty and social behavioral deficits. Our hypothesis that developmental mis-splicing of autism-risk genes causes myotonic dystrophy-associated autism is supported by these findings.
By Mahafuj Alamabout a year ago in Humans
The Human Brain Is Rewiring Itself Faster Than Ever
In recent years, scientists have begun to uncover something astonishing: the human brain is changing—fast. Thanks to rapid developments in technology, information overload, and the demands of modern life, researchers are discovering that our brains are not just adapting, but actually rewiring themselves in ways we’ve never seen before.
By Saad Ullah Khanabout a year ago in Humans
The Role of Technology in Cultural Evolution . Content Warning.
Thoughout history, technology has dramatically shaped human culture in various ways. From the earliest tools we relied on to the advanced systems we have today, technology has profoundly influenced how we communicate, express ourselves, and connect with each other. Let’s take a closer look at how technology has affected different aspects of human culture.
By Shariful Haque about a year ago in Humans
Your Brain Doesn’t Learn the Way We Thought, According to New Neuroscience Breakthrough
A recent breakthrough in neuroscience reveals that your brain does not learn in the same way we thought. Scientists and educators have relied on a few presumptions about how the brain learns for decades. Repetition, reinforcement, and the strengthening of neural pathways with use have dominated our understanding of learning and memory. However, a novel finding in neuroscience is challenging these assumptions and demonstrating that the brain learns in a manner that is significantly more dynamic and unpredictable than was previously thought. Pathways and Plasticity: The Traditional View. The concept of "synaptic plasticity," or the process by which connections between neurons (synapses) become stronger or weaker depending on how they are used, has been embraced by neuroscience for a long time. The expression "neurons that fire together wire together" is a well-known way to simplify this idea, which has been the foundation of everything from brain training apps to school curriculums. Repetition and feedback were thought to strengthen neural connections and gradually shape learning. The New Miracle: Learning by Surprise and Prediction. However, recent research suggests that the brain actively anticipates and adjusts in response to surprise rather than merely strengthening established neural pathways. The brain learns by constantly making predictions about incoming information and updating those predictions when they are incorrect, according to a Cambridge and MIT research team. Predictive processing is the name of this new model, which challenges the conventional concept of passive learning. The brain is more focused on errors, specifically the difference between what it expects to happen and what actually happens, rather than just strengthening connections through repetition. Learning is sparked by these "prediction errors." What This Means: Learning Is Driven by Error. The repercussions are significant. Exposure to novelty, challenge, and even mistakes could be more beneficial than rote repetition if learning is primarily driven by prediction errors. This could change the way we think about education, training, and even brain injury rehabilitation. AI modeling and cutting-edge imaging of the brain were used by researchers to study how neurons respond to unexpected information. The brain appears to selectively respond to moments of surprise rather than uniformly activating when learning something new, updating internal models to reduce errors in future predictions. Learning is iterative rather than linear. Additionally, the predictive model more closely resembles the iterative, non-linear nature of real-world learning. Think about how children learn to speak—not by memorizing words, but by hearing language, guessing, adjusting, and repeating. According to this finding, learning environments ought to be constructed in a way that not only reinforces but also challenges expectations. In a nutshell, the best way for us to learn is to be right when we are wrong. The Future of Brain Training and Education. It's possible that educational approaches will soon embrace surprise and productive failure. It's possible that environments that foster curiosity and experimentation, game-based learning, and adaptive testing are more in line with how our brains naturally function. In addition, this human insight may inspire more advanced learning algorithms, such as those that learn from deviation and expectation in addition to data. Last Thoughts. This breakthrough forces us to reevaluate not only our teaching methods but also our way of life and development. If the brain thrives on the unexpected, then maybe accepting the unknown, the challenging, and the unexpected is not a weakness; rather, it is how our brains are wired to learn. One of the researchers put it this way: "Our brains aren't just reacting to the world; they're also predicting it." Additionally, we learn the most when we make mistakes.
By Sia Janeabout a year ago in Humans
The Cases of Breakthrough Measles Infections, Why Do They Happen?
However, these breakthrough measles infections—measles infection in a vaccinated person—are rare but nevertheless laudable occurrences. The MMR vaccine is well-proven, but no vaccine gives 100% protection. With outbreaks of measles still emerging in countries around the world, particularly in those communities where vaccination rates are subsiding, it has been important to establish what the factor is for these breakthrough cases to occur, in order to facilitate public health awareness and landscape response [1].
By Asif Faysalabout a year ago in Humans