Vivian Creative
Stories (14/0)
DLL-3 as a Novel Target for Possible Lung Cancer Therapeutics
The Notch pathway is highly maintained to regulate cell proliferation, cell fate, differentiation, cell boundary construction, cell death, and several processes of growth and development in all metazoans. Delta‐like canonical Notch ligand 3 (DLL3) is a member of the Notch receptor ligand family and takes part in the Notch signaling pathway. High expression of DLL3 has been identified in small cell lung cancer and certain neuroendocrine tumors, while it is seldom observed in healthy normal tissues. This finding triggers the interest of developing DLL3 into a new target in cancer therapeutics, and some researchers have commenced their investigation on targeting DLL-3 for precision lung cancer treatment.
By Vivian Creative12 months ago in Education
Fluorescent Dye Probes for Biomarkers
Fluorescent dye probes or fluorophores are often described as fluorescent chemical sensors because they can absorb light at a given wavelength and emit light at a higher wavelength to produce fluorescence in various colors. Generally, they could be divided into organic dyes (e.g., fluorescein, rhodamine, AMCA), biological fluorophores (e.g., green fluorescent protein, phycoerythrin, allophycocyanin), and quantum dots. Due to the high sensitivity, technical flexibility, and quick response time of fluorescent dyes, they have become widely-used tools for quantitative detection and visual imaging.
By Vivian Creative2 years ago in Education
Relationship Between Non-Alcoholic Steatohepatitis and Autoimmunity
With the prevalence of obesity, diabetes, and other metabolic diseases caused by so-called "American high-fat and high-sugar diets", the nonalcoholic fatty liver disease (NAFLD) has increasingly become one of the major concerns worldwide. NAFLD may develop from simple steatosis into nonalcoholic steatohepatitis (NASH) and further progress to severe liver fibrosis, cirrhosis, and other end-stage liver diseases. Though lipotoxicity-elicited, innate, and adaptive immunity-mediated inflammation and subsequent autoimmune reactions are believed to be key pathological factors in the development and progression of steatohepatitis, the relationship between the immune system and NASH has not been completely characterized yet.
By Vivian Creative2 years ago in Education
Understanding Drug Resistance of Melanoma Brain Metastasis with Single-Cell Omics
Brain metastases, as its name indicated, means that cancer spread from the original site to the brain. All kinds of cancers are likely to spread to the brain and form one or more tumors in the brain, be it lung, breast, colon, or kidney. However, statistics in the United States show that only lung and breast cancers are the most frequent primary sites associated with brain metastases and approximately 10 percent of advanced melanoma patients would also develop brain metastases. Though the prognosis for melanoma brain metastasis (MBM) patients has been substantially improved due to advances in neuroimaging, improved disease management, as well as the development of immunotherapies, the understanding of the underlying biology behind MBM is relatively rudimentary and the treatment options for MBM remain limited, especially when it comes to the discovery of novel therapeutics.
By Vivian Creative2 years ago in Education
Finding the Best Animal Model Organisms for Biliary Atresia
Biliary atresia (BA) is a congenital condition that a blockage happens in the tubes responsible for carrying bile from the liver to the gallbladder. It results from abnormal development of the bile ducts inside or outside the liver and results in progressive fibrous obliteration with different degrees of inflammation in the hepatobiliary system. According to incomplete statistics, about 1 out of 10,000–20,000 live births would be identified with biliary atresia, but actually, the situation could be worse given the late diagnoses. Up to now, the causes for this condition remain unclear and seem to be heterogeneous, but it undoubtedly would lead to an inestimable mental and financial burden for patients and their families, as well as the healthcare system.
By Vivian Creative2 years ago in Education
Macrophages as Biomarkers of Non-Alcoholic Fatty Liver Disease Progression
Non-alcoholic fatty liver disease (NAFLD), as its name indicated, is a condition caused by abnormal or excessive fat buildup in liver, which is not a result of heavy alcohol use. It has become a common chronic liver disease and is affecting up to 25% of people worldwide. Most people have no symptoms, and 2% to 5% of people will experience complications from the fat in their liver and a more serious condition named non-alcoholic steatohepatitis (NASH) due to liver inflammation and cell damage, which ultimately could develop into liver cirrhosis. Thus, early detection is important before some irreversible results in the liver disease progression pose clinical and economic burdens.
By Vivian Creative2 years ago in Longevity
Paper-based Microfluidic Devices for Prototyping
It's acknowledged that the right selection of the material interface is of vital importance from research development to microfluidic platform applications and product transfer, in that one might be suitable for certain targeted applications but detrimental for another. The inherent microfabrication and specific physico‐chemical properties of each material dedicated to microfluidic applications are playing a dominant role in further microfluidic operability with both advantages and disadvantages.
By Vivian Creative2 years ago in FYI
How Camels Change the Antibody Engineering Industry?
In the late 1980s, researchers in a lab in Brussels found some old camel blood at the back of a freezer when extracting antibodies from human blood samples. Then, it was noticed that in addition to normal antibodies, some smaller antibodies devoid of light chains were extracted from the camel blood. Moreover, the heavy chains of these small antibodies were shorter and have only three domains, which lack the domain that binds the heavy chains to the light chains. This is how camelid antibodies came into sight by accident, which later proven to be a revolutionary finding for antibody engineering.
By Vivian Creative2 years ago in Earth
How to Prepare and Construct an RNA Sequencing Library?
RNA is a polymeric molecules composed of nucleotides that are required for gene coding, decoding, regulation, and expression. In molecular biology, DNA's genetic information gets transcribed into multiple copies of messenger RNA (mRNA), and then mRNA is translated into proteins. This is why cells can synthesize several protein molecules from a single gene at a given point of time. However, only 1-4% of total RNA are mRNA, the rest of which are generally non-coding, called non-coding RNA (ncRNA). ncRNA is unable to be translated into protein but there are many types of them, which have different biological functions.
By Vivian Creative2 years ago in Education
Single-cell Genomics Study Elucidates Human Cytomegalovirus Infection
Infection of β-herpesvirus human cytomegalovirus (HCMV) could be life-threatening or cause life-long suffering in the majority of humans. Moreover, the viral vertical transmission during pregnancy leads to most congenital birth defects. However, treatment and prevention options currently available are extremely limited.
By Vivian Creative2 years ago in Lifehack
Sulfonamides and Sulfonamide Hapten
Due to a low cost and general efficacy in common bacterial diseases, sulfonamides (SAs), the oldest antibacterial agents, are still widely used nowadays in human and veterinary medicine for the treatment and prophylactic purposes of infectious diseases and used as growth-promoting feed additives.
By Vivian Creative3 years ago in FYI
Bispecific Antibody Cellular Therapy Displays Anti-tumor Activity Against Lymphoma Cells
Researchers at the University of Texas MD Anderson Cancer Center recently conducted a preclinical study on combining cytokine-activated natural killer (NK) cells derived from donated umbilical cord blood with an investigational bispecific antibody (known as AFM13) targeting CD16a and CD30. The result of bispecific antibody cellular therapy displayed potent anti-tumor activity against CD30+ lymphoma cells.
By Vivian Creative3 years ago in Longevity