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"In What Furnace Was Thy Brain?"*

by D. Thea Baldrick 2 months ago in science
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How Alcohol Impacts Brain Cells and Why I Care

"In What Furnace Was Thy Brain?"*
Photo by Efe Yağız Soysal on Unsplash

*From "The Tyger" by William Blake

Most amino acids build proteins. Undeniably important, they are the basis of the body's structure. Nevertheless, some amino acids have other roles, roles that help sew together the vast complex of protein structures into a seamlessly moving, thinking creature.

GABA is an amino acid. It is also a neurotransmitter, tiny molecules that stream from one neuron to another in the brain by hazarding a synaptic gap, a liquid filled space. After crossing over, the minute molecules fit themselves to the cell's membrane at precisely formatted receptors particular to GABAs special shape. Now safely ensconced in its new home, GABA softens the cell’s response to stimuli. GABA, an acronym for an impossible-to-remember collection of letters, is a protective blanket, a favorite quilt the cell curls up with to get a good night’s sleep. It protects the cell from anxiety, from overstimulation, from the too-muchness of the world. When it is time, glutamate, another transmitter, made from GABA, a type of GABA offspring, pulls the blanket off, does a molecular imitation of a rooster crowing, and the healthy cell activates anew.

Enter alcohol. Through a twist of time, chance, and evolution it has a similar shape as GABA and attaches to the cell via the same receptor. In consequence, GABA itself is left homeless and ineffective. Meanwhile, the usurper pretends it is GABA. It is a blanket, too, but it is too heavy, too hot, and it itches. Following an initial feel-good episode in the brain due to alcohol-induced dopamine, the GABA imposter proceeds to smother the cell’s responses. Everything is muted. Pain sensations are dulled, sometimes toppling the body into lethal scenarios. Movement loses its grace. Memory is misplaced or lost. Decisions are made based on distorted, even delusional, reasoning. The cerebral cortex, the cerebellum, the hypothalamus, the amygdala, the hippocampus, none are spared.

Finally, glutamate production is slowed. There is no one to pull the covers off. The cell falls into lethargy; not just one cell, but most of them. Brain matter shrinks. The blanket becomes a shroud.

From Shutterstock

I am writing about the effects of alcohol on neuronal molecules because I am unable to write about my father who was an alcoholic. He died when I was twelve and he was forty-eight. He liked poetry and chess and watching MASH and building model airplanes. He read a lot, mostly history.

He loved his children. It just seemed like sometimes he loved alcohol more. I know it is not that simple. I even knew it then. He tried to quit many times.

He fought in the Korean War when he was nineteen. He was tall and thin and loped when he walked. He had prematurely gray hair. I memorized The Tyger by William Blake because he asked me and because he liked it and because I wanted to help him and I did not know how.

By Matias Luge on Unsplash

For a long time afterwards, until I was about twenty, every man I saw who was tall and thin with gray hair who loped when he walked, made me wonder if - even though I knew it was absurd - if perhaps the funeral had been a charade. There was no reason to think so except that I wanted it to be true. Once in a mall, I even followed a man, in order to walk past him, so I could look back and see his face.

His model airplanes are gone. No one knows where. His books are gone. No one knows where. I have a handful of letters he wrote. That is it.

One letter to my mother just after I was born begins, “Dear Love and Baby Love.”

His last letter to me ended with, “As your father, I have no intention of leaving you, for you will always be with me wherever I go, and I shall return to you.”

science

About the author

D. Thea Baldrick

By wedding two strange bedfellows, bachelor degrees in Biology and Literature, the resulting chimeric offspring are stories laced with science. I publish with thecollector.com and Underland Arcana. Unearth at dthea.com

Reader insights

Outstanding

Excellent work. Looking forward to reading more!

Top insights

  1. Heartfelt and relatable

    The story invoked strong personal emotions

  2. Eye opening

    Niche topic & fresh perspectives

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Comments (7)

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  • Jason Gretencord2 months ago

    Poignant and informative

  • LilyRose2 months ago

    Beautifully written!

  • Ashley Callea2 months ago

    Thanks for sharing! Hope to see more stories from you! 💫

  • Moi Li2 months ago

    Lovely piece. I enjoyed reading it quite a bit , I wished there was more :)

  • Gerard DiLeo2 months ago

    As someone keenly interested in neuroscience, neuroplasticity, NMDA receptors, and humans, and the high-jinx that ensues therefrom. And I found your GABA/glutamate discussion as eloquent as it was beautiful, which is hard to do away from a blackboard that puts students asleep. It was an excellent dovetail into your father, who lives forever, now, thanks to this.

  • Roger Scypion2 months ago

    Scientific and eloquently presented. My father passed away just as I was becoming a pre-teen. The part where you looked over every man resembling your father believing they may be him and he really isn't dead brought a tear to my eye. I can so relate.

  • Kathryn Wicker2 months ago

    I admire you for being so honest about such a horrible time in your childhood! The writer just captivated me from the science to your truth. Thank you for sharing!

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