Calvin Scheller
Stories (18/0)
The immune system
Inflammation can be both mechanically stimulated, such as a cut or a burn, or endogenously stimulated by the immune system to respond to foreign molecules within the body. Inflammation is necessary to detect, fight, and destroy these potentially harmful molecules. Moreover, the inflammatory response can lead to the formation of stronger mechanisms to combat a specific virus or bacteria in the future.
By Calvin Schellerabout a year ago in Longevity
Caffeine as an ergogenic aid
Logistically speaking, caffeine is likely the most easily accessible, and most prevalent, ergogenic aid for recreational consumption. Caffeine is a stimulant that itself is non-caloric, and provides no energy in the form of carbohydrate, fat, or protein. Thus, its energetic effects are not derived from the caffeine molecule itself, but are a result of the processes the presence of caffeine generates. The most regarded physiological mechanism by which caffeine enhances one's performance is its ability to block, or inhibit the action of adenosine. (Ferré, Sergi.) Adenosine is a byproduct of ATP utilization that builds up during exercise. Adenosine has receptor sites in the brain that, when bound to adenosine, downregulate one's production of excitatory and stimulating neurotransmitters. As adenosine receptor saturation increases, one will have greater perception of fatigue, and desire to sleep. Under normal conditions adenosine will progressively saturate the adenosine receptor throughout the course of the day. During sleep, the adenosine molecules that are bound to the adenosine receptors will be recycled for other physiological functions, such as the regeneration of ATP. Caffeine also has the ability to bind to an adenosine receptor, but it does not produce any action. In essence, Caffeine inhibits adenosine from binding to the adenosine receptor, thus terminating the progresive development of fatigue. Due to the limited number of receptor sights, caffeine will bind to the available adenosine receptors and block the adenosine molecule from binding and promoting drowsiness and fatigue. One caveat to the process of adenosine inhibition is that adenosine production does not come to a standstill. One will continue to create adenosine as a byproduct of ATP utilization, however the adenosine molecule is unable to bind to its receptor to downregulate one's nervous system. Consequently, unbound adenosine levels accumulate during the period of time caffeine is inhibiting the adenosine receptor, and as caffeine metabolizes there is a high concentration of unbound adenosine molecules that have accumulated in the presence of caffeine. Additionally, caffeine will increase the secretion of catecholamines, most notably adrenaline. Catecholamines are hormones that serve a plethora of effects on our body, the predominant effect being an increased tolerance to pain, an increased awareness, and a priming effect on one's muscular system. We naturally secrete catecholamines in response to pain, and they play a pivotal role in decreasing one's perception of pain and fatigue during exercise. Furthermore, an increase in catecholamine stimulates a multitude of processes that prime one for a physical exertion. For example, catecholamines can bind to cell receptors that stimulate the release of calcium located inside the cell. Calcium subsequently binds to a receptor named Troponin C, which consequently alters the potential of a cell to allow for a muscle to shorten. (Guest, Nanci S., Kuo, Ivana Y) Furthermore, caffeine increases our fuel availability in the form of fatty acids, and glucose in our blood stream. (Institute of Medicine (US) Committee on Military Nutrition Research.) As mentioned, catecholamines upregulate a series of processes that prime an individual for a physical exertion. Catecholamines bind to receptor sites on adipose tissue and stimulate the release of fatty acids from adipose tissue to be mobilized, or released, into the bloodstream to make it readily available to the cell to create ATP. When fatty acids are available in unison with glucose, fatty acids can be used simultaneously alongside the available glucose for ATP production. Inevitably allowing for a certain degree of glucose preservation due to a reduced need to rely primarily on glucose for energy production during aerobic respiration. Due to the relative low intensity of endurance sports, athletes have available oxygen to undergo aerobic respiration. When energy needs increase to a level that surpasses our capacity to supply oxygen, we begin to metabolize glucose in order to fuel source anaerobic cellular respiration. Due to the duration of an endurance event, an athlete will typically have enough oxygen available to maintain a state of aerobic respiration. Anaerobic respiration allows an athlete to metabolize either carbohydrates or fatty acids to provide the energy needed for cellular respiration. Conversely, at the end of a race, in which an athlete would typically begin to sprint, an athlete loses the ability to consume enough oxygen to keep them in a state of aerobic respiration, inducing hypoxia, requiring cells to undergo anaerobic respiration. Glucose is the required fuel source for anaerobic respiration, and fatty acids cannot be used to fuel cellular respiration without the presence of oxygen. Caffeine is advantageous due to its ability to allow fatty acid metabolism during the earlier, aerobic, components of the race, thus allowing for the preservation of the glucose required for anaerobic respiration in the later components of an event.
By Calvin Schellerabout a year ago in Longevity
Did humans evolve to be carnivores
Evolution of the human diet Natural selection indicates that as organisms evolve, the organisms that adapt to their environment to the greatest degree eventually reproduce, and organisms that are unable to act in congruence to their environment do not survive long enough, or healthlly enough, to reproduce. Thus, as organisms evolve they will adopt behaviors that allow for the most optimal health and vitality, and will terminate harmful and non beneficial behaviors. For example, throughout our entire evolution, humans have maintained the behavior of sleep. At face value, sleep is simply a period of time in which mammals are unable to carry out any productive behaviors. Furthermore, a sleeping organism is at a much greater risk of being killed by a predator due to unconsciousness and immobility. If sleep was not absolutely necessary for their health and vitality, the organisms that thrived throughout history would likely be the organisms that did not require sleep. Understanding natural selection allows one to look at the habits that have been consistent throughout evolution and determine the dietary behaviors that supplied humans with the most optimal mental, and physical function. The most accurate form of determining the diet throughout human evolution is through studying stable carbon and nitrogen isotopes of the bones of dead organisms. The results of isotope studies of late Neandertals indicates that humans evolved as carnivores who derived the majority of our energy from large herbivorous animals. Further, humans were likely at the top of the food chain, that is humans were the apex predators. (1) Simply put, when given the opportunity humans would hunt, kill, and eat animals to fulfill their energy requirements. It is estimated that Neandertals' diets were derived from no less than 80% of energy obtained from animals. Furthemore, the simple yearly availability of non animal products would fluctuate throughout the year. If humans were not capable of subsiding strictly off of animal nutrition, early humans would not have survived during times of extreme weather that reduced their accessibility to any nutrition other than animals. When large animals were available for consumption, that was the preferred source of energy. Fruits and vegetables were eaten for subsistence between successful hunts, and simply for entertainment. These actions were performed in the absence of scientific reasoning, rather based on what produced the most beneficial outcomes in the past. With our current availability of food, we are capable of having an abundance of animal food present whenever we need to fulfill our energy requirements, thus we have no need to use plant energy for subsistence until we can obtain animal products.
By Calvin Schellerabout a year ago in Longevity
Caffeine sensitivity
As wearable technology is improving, and becoming more easily accessible, you are provided with new opportunities to improve your overall health and well-being using feedback from wearable technologies, such as smart watches and rings.
By Calvin Schellerabout a year ago in Longevity
Lectins
Introduction It is often assumed that the benefits of a diet are from the foods that we include, but I would postulate that many of the effects come from the removal of foods that are detrimental. Moreover, you may have persisting syomtoms that are not due to your current diet, but actually due to foods that you are in the past!
By Calvin Schellerabout a year ago in Longevity
Biochemistry of thyroid production
Introduction There are two hormones in humans are triiodothyronine (T3) and thyroxine (T4) that are responsible for the effects of thyroid function however, there is a cascade of events that must occur beforehand to make their production possible moreover, the presence of specific molecules and nutrients must be sufficient to produce these hormones in the first place Both of these hormones are composed of tyrosine and iodine, however T3 contains three iodine molecules and T4 contains four. T4 is considered the inactive form of thyroid hormone, and T3 is the active form. That is, in the cell T3 is the necessary form of the hormone for thyroid activity. T4 is very easily converted into T3, as we will discuss in a moment. Through a series of signals through the hypothalamic pituitary axis (HPA), we somehow come out on the other side with T3 and T4 being secreted into the bloodstream by the thyroid gland. However, there are many prerequisites that must take place before any of that can ensue.
By Calvin Schellerabout a year ago in Longevity
The biology of taste
Taste is a sensation that is triggered by the presence of specific molecules on the tongue. These molecules stimulate a cellular response within cells on the tongue. The result is the activation of specific nerves that send a signal to the brain and are interpreted. Humans have 5 tastes that we can distinguish, each having a specific receptor. Humans can detect sweet, salty, bitter, sour, and umami molecules on the tongue. Each of these taste sensations are activated by different molecules, and there are a multitude of molecules that stimulate a given taste sensation.
By Calvin Schellerabout a year ago in Longevity
How many rest days should I take
By far one of the most common questions when it comes to exercise is, "how many rest days should I take?" By God, I wish I could answer this question accurately and tell everyone how many rest days they actually needed. But I simply cannot. Recovery is very complex, and there are a myriad of factors outside of simply the stress of training that affect one's recovery. Stress is stress. Whether it is work stress, family stress, relationship stress, training stress, it's all stress
By Calvin Schellerabout a year ago in Longevity
Hacking the human mind
. Human psychology is radically complex, and I will be the first to tell you that all of my opinions are subject to change. However, I recently made a very interesting observation, it seems to have support when it is put to the test in scientific studies.
By Calvin Schellerabout a year ago in Longevity
Anti-inflammatory steroids
Anti-inflammatories and your muscle In order to grow muscle, we need to stress a muscle more than it is currently adapted to handle, which will produce a degree of inflammation. It is this inflammation that is used as the initial signal that the muscle needs to be repaired. And, if there is sufficient material (amino acids mostly) then we will increase the size of the muscle, which could come in the form of larger muscle cells (Hypertrophy) or cellular division that increase the number of muscle cells (Hyperplasia). The inflammation induced by training is important for the repair to continue. Anti-inflammatories, as the name implies, will reduce the inflammation, and inhibit the signal. These compounds reduce the signal for the body to adapt and enlarge the muscle, and muscle growth is handicapped.
By Calvin Schellerabout a year ago in Longevity