Spravato: Innovative Nasal Spray Treatment for Depression

Spravato (esketamine) is a groundbreaking, FDA-approved medication used for treatment-resistant depression (TRD). Administered as a nasal spray under medical supervision, Spravato works differently than traditional antidepressants by targeting NMDA receptors in the brain. This novel mechanism offers rapid relief from depressive symptoms, often within hours or days rather than weeks.

At Lotus Psychiatry and Wellness, we are proud to offer Spravato to patients who have struggled to find success with conventional therapies. Our team is dedicated to guiding you through this advanced treatment option with care, safety, and expertise.

How Spravato Works

Spravato is derived from ketamine, a well-known anesthetic with fast-acting antidepressant properties. Unlike SSRIs and SNRIs, which affect serotonin and norepinephrine, Spravato targets the glutamate system, which plays a key role in mood regulation, memory, and cognition.

The treatment helps:

• Form new neural connections in the brain

• Restore synaptic function damaged by chronic depression

• Rapidly improve mood and cognitive clarity

Patients often begin to notice improvements in mood and functioning within hours to a few days after their initial treatments.

Who Is Eligible for Spravato Treatment?

Spravato is FDA-approved for adults who:

• Have major depressive disorder (MDD) and have not responded to at least two other antidepressants

• Experience treatment-resistant depression (TRD)

• Are not currently dealing with active psychosis or certain medical conditions that would make ketamine use unsafe

Before starting treatment, our team at Lotus Psychiatry and Wellness will conduct a thorough psychiatric and physical evaluation to determine if Spravato is the right fit for you.

What to Expect During Spravato Treatment

Spravato is administered in-office at Lotus Psychiatry and Wellness under close supervision by trained healthcare providers. Here's what a typical treatment visit looks like:

1. Pre-Treatment Evaluation – Vital signs and mental state are assessed.

2. Spravato Nasal Administration – The patient self-administers the nasal spray under guidance.

3. Monitoring Period – You’ll relax in a quiet, comfortable room for about two hours while our staff monitors for side effects and changes in mood or blood pressure.

4. Post-Treatment Discharge – Once cleared, a trusted family member or friend must drive you home, as Spravato may cause temporary drowsiness or dizziness.

Most patients begin with twice-weekly treatments for the first month, followed by weekly or biweekly maintenance sessions based on response and progress.

Benefits of Spravato Therapy

Spravato offers several advantages for those who have not responded to other depression treatments:

✔ Rapid Onset of Action

Unlike oral antidepressants, which may take 4–6 weeks to work, Spravato can deliver results within hours or days.

✔ Effective for Treatment-Resistant Depression

Many patients who have tried multiple medications without success experience significant symptom relief with Spravato.

✔ Safe, Supervised Administration

All treatments are conducted in a controlled clinical setting, ensuring patient safety and optimal monitoring.

✔ Lasting Relief

Paired with talk therapy and follow-up care, Spravato has helped many patients achieve long-term symptom reduction.

Side Effects and Considerations

While Spravato is generally well tolerated, some patients may experience temporary side effects such as:

• Dizziness

• Nausea

• Fatigue

• Increased blood pressure

• Dissociation (feeling disconnected from reality)

These effects typically subside within a few hours. Our care team monitors patients closely during and after each session to ensure safety.

Spravato is not habit-forming when used correctly under professional supervision and should always be taken as prescribed and within a structured treatment plan.

Why Choose Lotus Psychiatry and Wellness for Spravato Treatment?

At Lotus Psychiatry and Wellness, we specialize in personalized mental health care using advanced treatments like Spravato and TMS. Our clinic offers:

• Board-certified psychiatrists with expertise in treatment-resistant depression

• A calm, private treatment environment designed for healing

• Compassionate, one-on-one patient support throughout the entire process

• Ongoing evaluation and mental health therapy to support long-term outcomes

We believe in treating the whole person—not just the symptoms—using a blend of modern science and individualized care.

Begin Your Journey to Healing Today

If you’re struggling with depression and haven’t found relief with traditional medication, Spravato may be the answer. The expert team at Lotus Psychiatry and Wellness is here to walk with you every step of the way.

Contact us today to schedule a Spravato consultation and learn if this innovative treatment is right for you.