Can the new possible cure stop HIV?

it is the 12 months 2040. A scientist looks at all of the notes he has scribbled over the last decades.

It become difficult work.. but sooner or later he located a cure for HIV. So how did he get there? it all started out

within the 90s with a person named Tim. Tim is from the u.s. and moved to berlin for university.

He enjoyed his life inside the city and frequently visited berlin's well-known golf equipment. but then his time in berlin

took a turn. One night time Tim woke up in a sweat. He had fever and chills. He wasn't too worried he

in all likelihood simply got unwell. The fever finally vanished and he forgot about the incidents.

but multiple weeks later Tim had a few recurring checking out and turned into recognized with HIV.

This meant that Tim had to begin taking capsules for the relaxation of his life to suppress the virus.

So he did that and for some time the entirety changed into pretty best until Tim started out to feel exhausted

and dizzy multiple months later. because of his HIV diagnosis he right away called his medical doctor

who carried out a blood test. The take a look at didn't display any abnormalities concerning his HIV infection.

as a substitute he had a lack of red blood cells so further assessments had been carried out and Tim was

identified with leukemia. This changed into horrible information but his physician had an idea: and he cured tim's HIV

infection and cancer right now. that is the story of a rare case wherein hIV has been cured inside the beyond.

however this might quickly change. Scientists are currently searching for a conventional cure for

HIV. My call is Clemens Steinek and today we're going to speak about feasible HIV treatment plans of the destiny.

We once talked approximately how HIV was cured in guy and another

time how we broaden hiv vaccines. when the scientist in our tale became a teen he heard

approximately Tim and decided to commit his lifestyles to HIV studies. So he did what everyone could do.

He deleted his instagram and tiktok account and started to observe the virus with a purpose to understand

how it works. HIV or the human immunodeficiency virus is a virus that infects people and reasons

AIDS. it's miles envisioned that over 38 million people are inflamed with HIV. whilst HIV enters

the body it circulates inside the blood and tries to infect cells. HIV is specialised to infiltrate a

unique sort of immune cells referred to as CD4 high quality T cells. The virus uses the protein CD4 and CCR5 on

the surface of the cell for its entry. If that happens the frame recognizes the infection and

starts to fight the virus. in this level inflamed humans frequently expand fevers or sweats. given that these

signs are very similar to flu symptoms however HIV infections regularly remain undetected for a protracted

time. The fever vanishes after more than one days and for the following months the inflamed man or woman frequently

doesn't realize that anything is inaccurate. but there may be something incorrect. in the affected person HIV starts its

vicious cycle. once the cell has been infected HIV integrates its genetic statistics into the DNA of

the host cellular. Then the virus often would not do some thing for a totally long time. It just stays

in the DNA of the immune cell and is inactive. Slowly but HIV turns on itself and makes

new viral particles. It copies its genetic data over and over once more and carries

small errors which adjustments the structure of HIV. And that is awful as HIV might emerge as

resistant towards tablets or have less and much less problems to escape any immune responses. The host

cellular finally bursts and the launched HIV particles can infect new cells. And this is going on for months.

Slowly the patient loses an increasing number of T cells and the immune device would not paintings properly anymore.

If HIV remains untreated patients enter the very last stage of the contamination known as AIDS. symptoms of

AIDS consist of recurring fever, weight reduction, pores and skin rashes and continual white spots or lesions

around the tongue or mouth. The immune gadget has been damaged so much that it does not work

well anymore. as a result different bacteria or viruses which might be normally now not harmful to us

infect aids sufferers leading to the deaths. HIV capsules ordinarily try to mess with the lifestyles cycle of

the virus to keep the number of active debris low. which means HIV can be treated however it

additionally method that capsules ought to be taken a lifelong. HIV can also become resistant over time which

way that the medication do now not work nicely anymore. And these are motives why we want a therapy for HIV.

Seeing his notes the scientist recollects how many hours he spent gaining knowledge of a deadly disease earlier than he found

a remedy. He read numerous research or even watched random ancient movies on youtube.. wow it is

meta. HIV looks as if this sort of nasty virus. it could enter immune cells it could continue to be internal cells for

years and adjustments very quickly over the years. In his desperation his scientists sat down on his sofa

and commenced to binge watch squid recreation. midway thru he eventually had the concept. He notion

we want to address those three characteristics. We need to forestall the access of HIV it is lengthy survival

and we need to locate approaches to conquer the diversity of the virus. How are we going to do this? So right here

are three methods which may help to treatment HIV one day. the primary one is genetic engineering. Genetic

engineering is a process where we brought genes in an organism. you might keep in mind that HIV uses

CCR5 to contaminate cells and by way of changing this gene the virus must now not be capable of achieve this anymore.

In precept it works like this. we can for example import a Cas protein and a piece of rna

into immune cells to regulate the ccr5 gene. the usage of this piece of rna the Cas protein is then guided

to the ccr5 gene. The Cas protein then makes a reduce in a DNA that's diagnosed by using the cell.

The cellular then tries to seal the spoil which is form of complex however the important thing is

that it would cause adjustments in the CCR5 gene. And scientists have virtually celebrated

first successes using genetic engineering. In 2010 immune cells have been isolated from a human

and genetically altered to disrupt CCR5. Afterwards the genetically engineered cells had been

transplanted into mice that have been inflamed with HIV. The genetically engineered immune cells

in large part survived in mice at the same time as the ranges of HIV decreased. a chunk more latest genetic engineering

become extensively utilized in first clinical trials. here immune cells had been remoted from HIV patients. CCR5

was disrupted and the cells had been then placed lower back into the sufferers. here it become additionally proven that

genetic engineered cells lived longer than immune cells which means that it is able to be partial resistance.

however once more this kind of technology has just commenced. We want to find out where this technique

is truely possible to make an HIV remedy. but it really is not a situation in 12 months 2040 anymore. The scientist

of our tale has determined several methods to treatment HIV. besides the usage of genetic engineering this scientist

has also evolved latency reversal or shock and kill. HIV is nasty as it could conceal in cells for

years whilst it slowly destroys the immune system and every of these HIV sequences should awaken

at any time and infect in addition cells. but why no longer wake up all the inactive HIV debris right now and

damage them? And this method is referred to as surprise and kill or latency reversal. The drug disulfiram

can trigger inactive HIV debris to in part grow to be activated. that is then recognized by way of

other elements of the immune device which assault HIV inflamed cells. on the equal time we provide

the affected person traditional capsules to inhibit the activated viruses from spreading. We do this over

and over again and over time this could spoil all the final HIV debris. There had been

more than one clinical trials looking to set off HIV. In a segment 2 study disulfiram became used in 30

HIV patients. It became observed that the drug improved the stages of HIV debris in patients. And just

to emphasise the sufferers on the identical time also took traditional pills so no person become harmed. So

some distance but this technique hasn't been effective enough. We really need to dispose of all of the

hidden hiv debris even the smallest surviving population could reason AIDS. The 1/3 approach

to cure HIV is immunotherapy. Immunotherapy approach that we stimulate the affected person's very own immune system

to wreck HIV particles. during the last years increasingly so-called extensively neutralizing

antibodies had been determined in HIV patients. We protected them in another video where we communicate

approximately HIV vaccines so test that out if you're interested. those antibodies understand areas

of HIV which might be regularly not modified. we have seen that HIV can change its form very quickly whilst

making new debris. however not all parts of HIV can be freely changed with out going through effects.

a few parts of HIV as an example are critical for a structure and their disruption would result in the

disintegrate of the virus. we will now use antibodies against those areas which assist the immune device

to ruin HIV. in a single have a look at it was investigated whether or not widely neutralizing antibodies may be

used in opposition to HIV-like viruses. ere it was proven at monkeys which were dealt with with the antibodies

where in part covered from infections with the virus. In any other study two widely neutralizing

antibodies were given to HIV sufferers and led to lengthy-term enhancements in patients.

And also right here the primary effects are promising but we want to broaden these remedies similarly.

back to the 12 months 2040 the scientists studied HIV and helped to expand a cure.

he's now peaceful. He has executed his paintings he will now reactivate his tiktok account which

has become a discussion board for philosophical discussions over the past a long time. i hope that you have seen

that even though there is no treatment for HIV scientists are operating tough to conquer this virus.