the US pop star wrote: "I'm starting to feel like the world doesn't want me in it."
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She did not clarify if this meant she was leaving the music industry or social media.
"I'm getting tired of putting up with being dragged by everyone in my life and on the internet," Lizzo wrote.
Last August, three of her former dancers sued Lizzo over claims including sexual harassment and creating a hostile work environment.
Arianna Davis, Crystal Williams and Noelle Rodriguez are the former dancers bringing the case against the singer, her dance captain and her production company.
The legal action includes accusations of sexual, religious and racial harassment, discrimination, assault and false imprisonment.
Lizzo is also accused of fat-shaming Ms Davis on tour.
The singer - whose real name is Melissa Viviane Jefferson - said the allegations were "false" and as "unbelievable as they sound".
Lizzo was last seen on Thursday where she performed at Radio City Music Hall in New York for a fundraiser for US President Joe Biden.
Lawyer Ron Zambrano, who represents the three former dancers, reportedly told NewsNation: "It's shameful that Lizzo would be chosen to headline an event like this amid such egregious allegations READ MORE....
BBC News has contacted Lizzo's agent for comment.
Lizzo accused of sexual harassment and fat-shaming
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