Two-Photon Microscopy Market – Global Industry Analysis, Size, Share, Growth, Trends and Forecast

The global two-photon microscopy market was valued at USD 127.2 Million in 2019 and is projected to reach USD 185.1 Million by 2027, expanding at a CAGR of 5.2% during the forecast period. Two-photon microscopy stated to as two-photon laser scanning microscopy, is an improvement of accuracy fluorescence microscopy. In confocal or epifluorescent microscopy, a single photon of light at a specified wavelength causes the fluorophore to release light. In two-photon microscopy, the fluorophore can be activated by efficiently absorbing two-photons concurrently. In this case, each photon itself has a wavelength that is double the normal wavelength of excitation, and has half the energy level per photon. Once the fluorophore consumes the two low-energy photons around the same moment, each adds half of the excitation energy required to communicate with the fluorophore, as it has been hit by a single photon of more energy and a short wavelength.

Market Dynamics

Major established players dominate the market, thus creating hindrances for new players. The introduction of two-photon microscopy, helps companies cater to several consumers and increases their market presence. Opportunities for new players to enter the market are low due to high initial investment and strict regulation pertaining to two-photon microscopy manufacturing. Less availability of raw materials due to pandemic and increased R&D for manufacturing of two-photon microscopes are expected to increase the bargaining power of suppliers. Buyers have access to refurbished products, as most of the two-photon microscopes and their accessories can be reused; therefore, the bargaining power of buyers is moderate.

The exact substitution of two-photon is currently unavailable in the market; however, other microscopic techniques such as confocal and three-photon microscopy techniques are being used by several end-users. This, reduces the growth of two-photon microscopy among conventional end-users. The software of two-photon microscopy is trending among end-users due to their highly efficient outcomes with the requirement of less efforts and manpower.

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Rising Focus on Nanotechnology

Nanomaterials provide lightweight and efficient components for applications in the automobile and building industries. Nanotechnology in coatings makes surface products durable, water-resistant, and stain-resistant, thus providing options for high street fashion and high-end athletic equipment in the clothing industry. Many high-performance electronic devices depend on nanotechnology, for example, Quantum Dot (QD) technology for LED displays and smartphones (QDs provide high quality and reliable color reproduction). Global investment in nanotechnology is expected to be equivalent to USD 4 trillion. Out of which China and the US together are spending more than USD 2 billion during the forecast period. Growing emphasis on nanotechnology research, which is heavily financed by private enterprises and governments, facilitates the procurement of sophisticated automated microscopes by numerous research institutes. This, in turn, is projected to boost the two-photon microscopy market rapidly during the forecast period.

Increasing Application Areas of Two-photon Microscopy

Scientists have been improving microscopes ever since the devices were invented in the late sixteenth century, and have accelerated significantly over the past decade. The infrared excitation light which is used in the two-photon microscopy is not as much harmful to the biological samples; with UV-excitable fluorophores than those utilizing UV light. Two-photon microscopy has allowed for a greater understanding of these processes within living cells. Technological advancements proven in current applications of the two-proton microscopy have led to faster imaging of embryos, comprising those of zebra fish and fruit flies while maintaining viability. Each microscope technique involves a compromise. Many advances have been made using these microscopy tools. The two-photon microscopy is used in many industrial applications such as automotive, machinery, and water treatment. Hence, increasing application of two-photon microscopy is estimated to boost the market during the forecast period.

Regional Outlook

In terms of regions, the global two-photon microscopy market has been fragmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America is a promising region for the market. The market is this region constituted 42.0% share of the global market in 2020. The market in Asia Pacific is projected to expand at a CAGR of 5.7% due to the increase in government spending, rising awareness about two-photon microscopy, and growing consumer base in the region.

Competitive Landscape

• Bruker
• Leica Microsystems
• Nikon Instruments Inc.
• OLYMPUS CORPORATION
• ZEISS International.

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