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Omicron is rapidly becoming a major epidemic strain; men with "bad feelings" have higher levels of inflammation.

The newest global technological information.

By gaisndm HawkshawPublished 2 years ago 5 min read

Health.

Men with multiple breakups and long-term solitude have higher levels of inflammation.

Divorce, breakup, and the long-term solitude that may follow may affect people's physical and mental health, but previous studies have focused on the effects of a single breakup and divorce.

A new study published in the Journal of Epidemiology and Community Health studied the effects of multiple breakup of relationships (including breakups) and long-term solitude, and found that among men, these experiences are strongly associated with elevated levels of blood inflammatory markers.

Omicron strain is rapidly becoming a major epidemic strain.

The report points out that with the spread of Omicron strain, the prevalence of Delta strain began to decline, and community transmission of Omicron strain has occurred in many countries.

Of the 357,206 virus gene sequence samples collected in the past 30 days, 58.5% were Omicron strains, and the proportion of Delta strains decreased to 41.4%.

World Health Organization (WHO) said that the Omicron strain has a significant transmission advantage and is rapidly replacing other strains as the main epidemic strain.

(CCTV News).

Medical science.

Synthesis of drugs in mice to cure cancer in mice.

The treatment of cancer is a world-class medical problem, one of its main challenges is how to reduce the toxic and side effects of treatment on the body, drugs that can kill cancer cells often cause damage to normal cells.

Recently, researchers have developed a new treatment method for in situ synthesis of anticancer drugs in cancer tissue using metal catalysts, which avoids the indiscriminate damage of drugs to healthy tissues and is expected to have a significant impact on cancer treatment. the results are published in Nature Letters.

In general, when the catalyst is injected into the organism, it will be destroyed by antioxidants such as glutathione, and if the metal catalyst is encapsulated in the protein carrier, it can stably perform the catalytic function in the body.

By attaching the sugar molecular chain that specifically recognizes cancer cells to the surface of the carrier protein, the transition metal catalyst can be selectively delivered to the cancer tissue, and the catalyst will further synthesize the benzene ring skeleton needed for anticancer drugs. improve the anti-cancer activity of drugs.

Using this technique, researchers can inject drug precursors and transition metal catalysts into mice intravenously, thus successfully inhibiting tumor growth and metastasis.

This method realizes in situ synthesis of active anticancer drugs for the first time, which has a far-reaching impact on the development of new methods for cancer treatment.

Cell biology.

How skin cells become the first line of defense against cancer.

CSDE1 is a kind of RNA binding protein.

Previous studies have suggested that the protein is associated with the formation and proliferation of a variety of tumors, such as promoting the metastasis of melanoma.

Recently, a new study published in the Cell report found that CSDE1 plays an important role in inhibiting cancer and reveals the molecular mechanism by which CSDE1 proteins coordinate different pathways and help skin cells fight cancer.

The researchers collected keratinized cells from mice that can cause all kinds of skin cancers, including basal cell carcinoma and squamous cell carcinoma, to induce the cells to enter a state of aging.

They found that when CSDE1 is cleared, cells do not age, but become "immortal" cells that can continue to reproduce and divide.

After CSDE1-scavenging cells were implanted subcutaneously in mice, all mice developed malignant tumors within 15 to 20 days.

Further studies have shown that CSDE1 inhibits tumorigenesis through two independent mechanisms: one is to induce cells to secrete cytokines and enzymes to permanently stop cell growth; the other is to inhibit the synthesis of YBX1 protein which can promote tumor growth and enhance tumor invasiveness.

The researchers say whether CSDE1 protein can fight cancer depends on the type of cell and tissue in which it is located.

In the future, RNA-binding protein may become a new target for the treatment of diseases.

Astronomy.

Shanghai Observatory discovers a galaxy in the era of "cosmic reionization"

The cosmic reionization process took place about 13 billion years ago.

Before this process, hydrogen, the most abundant element in the universe, existed mainly in the form of neutral atoms, which became charged ions under the action of the first generation of stars, galaxies and black holes.

This process is related to the birth of the first generation of celestial bodies in the universe, is the last major phase transition of the universe as a whole, and is of high research value.

However, because the signal is too weak, scientists can not directly observe the process of Lehmann ionization photons on the surrounding neutral hydrogen produced by galaxies during the reionization of the universe.

At present, only more than ten samples with redshift less than 4 can be studied on the escape of Lehmann ionized photons in galaxies.

Climatic change.

Ocean warming once again set a record.

After breaking the record for several years in a row, the accumulated heat of the ocean reached a new high again in 2021.

Scientists from 14 institutions analyzed ocean heat data from the Institute of Atmospheric Physics of the Chinese Academy of Sciences and the Environmental Information Center of the Oceanic and Atmospheric Administration (NOAA) from the 1950s to 2021, and recently published their analysis in the journal advances in Atmospheric Science.

According to the research, the area within 2000 meters of the upper layer of the global ocean in 2021 absorbs more than 1.4 × 1022 joules of heat than in 2020, which is equivalent to 145 times of the total global power generation in 2020.

Warming reduces the ocean's ability to absorb carbon dioxide, leaving more greenhouse gases in the atmosphere.

The researchers used independent forcing experiments from the Earth system Model (CESM) of the National Center for Atmospheric Research (NCAR) to reveal the contribution of different forcing factors to ocean warming.

The experimental results show that the increase of greenhouse gases is the main reason for driving the spatial structure of ocean warming. In addition, industrial and biological aerosols and land use also have a certain impact on ocean warming.

Scientists have warned that ocean temperatures will continue to rise before "net emissions" fall to zero, with a series of consequences such as rising sea levels and extreme weather.

Science

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    gaisndm HawkshawWritten by gaisndm Hawkshaw

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